Efficacy of Orthoapnea Mandibular Advance Device in Patients with Mild and Moderate Obstructive Sleep Apnea Syndrome

Rationale: Continuous positive airway pressure (CPAP) is the treatment of choice in patients with Symptomatic Obstructive Sleep Apnea Syndrome (OSAS). Recently, Mandibular Advancement Devices (MAD) are used in the treatment of OSAS. Objective: Investigate the efficacy of the Orthoapnea MAD in patients with mild or moderate OSAS in adults. Methods: This is a prospective study. Patients diagnosed with mild or moderate OSAS by Respiratory Polygraphy were included. A Basal Polygraphy and 3D scan was performed and repeated after four weeks of treatment. The treatment was considered effective when an AHI lower than 5 or a significant reduction was reached. Results: 103 patients were included: 84 men and 19 women; average age of 46.47 9.71; Body Mass Index average of 27.36 2.45 kg/m2. The airway area patency and volume increased after the treatment (area from 256 to 308 mm2; volume from 4533 to 6356 mm3). After treatment statistically significant decreases (p<0.05) were obtained in average AHI (from 16.2 to 6), both in supine (from 25.1 to 6.9) and prone position (from 7.8 to 3.9); Desaturation per hour Index Average (from 13.7 to 5.5); average CT90 (from 1.6 to 0.6). In 72.80% of the cases the AHI was halved. In 90.30%, an AHI under 10 was reached and, in 61.2%, under 5. Conclusions: The use of Orthoapnea MAD proves to be an efficient therapeutic alternative, increasing airway area patency and volume, thus reducing the AHI and desaturation for patients with mild and moderate OSAS.